http://radiographics.rsna.org/content/21/2/439.full
Caroline Chiles, MD ; Pamela K. Woodard, MD ; Fernando R. Gutierrez, MD ; Kerry M. Link, MD

1 From the Department of Radiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157 (C.C., K.M.L.); and the Department of Radiology, Mallinckrodt Institute of Radiology, St Louis, Mo (P.K.W., F.R.G.). Presented as a scientific exhibit at the 1998 RSNA scientific assembly. Received April 7, 2000; revision requested May 30 and received July 28; accepted August 3. Supported by the RSNA Research and Education Foundation.

Metastases to the heart and pericardium are much more common than primary cardiac tumors and are generally associated with a poor prognosis. Tumors that are most likely to involve the heart and pericardium include cancers of the lung and breast, melanoma, and lymphoma. Tumor may involve the heart and pericardium by one of four pathways: retrograde lymphatic extension, hematogenous spread, direct contiguous extension, or transvenous extension. Metastatic involvement of the heart and pericardium may go unrecognized until autopsy. Impairment of cardiac function occurs in approximately 30% of patients and is usually attributable to pericardial effusion. The clinical presentation includes shortness of breath, which may be out of proportion to radiographic findings in patients with pericardial effusion or may be the result of associated pleural effusion. Patients may also present with cough, anterior thoracic pain, pleuritic chest pain, or peripheral edema. The differential diagnosis of pericardial effusion in a patient with known malignancy includes malignant pericardial effusion, radiation-induced pericarditis, drug-induced pericarditis, and idiopathic pericarditis. Any disease process that causes thickening or nodularity of the pericardium or myocardium or masses within the cardiac chambers can mimic metastatic disease.